Ammonia → Quinoline-6-carboxamide

HRID 876791

反応式

HRID 876791 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11](Cl)=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[NH3:14]>C1COCC1>[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH2:14])=[O:12])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 222AmmoniaHCID 12391963Quinoline-6-carbonyl chloride

生成物 1

HCID 11052097Quinoline-6-carboxamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of quinoline-6-carbonyl chloride (0-2) (2.2 g, 10.5 mmol) in THF (100 mL) was added ammonia (5 mL) at 0° C. The mixture was stirred at room temperature for 1 h, then concentrated and washed with water (15 mL) to afford the title compound (1.5 g). MS (m/z): 173 (M+1)+.

後処理

  1. concentrationconcentrated
  2. washwashed with water (15 mL)

出典と根拠

ORDレコード
ord-87238a64770048ebb9f0b78f6339b255
出典データセット
uspto-grants-2015_03
特許番号
US08987269B2

関連ノート

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