Formic Acid → HCID 178507597、化合物
反応式
[Cl:1][C:2]1[N:7]=[C:6]2[S:8]C(N)=[N:10][C:5]2=[CH:4][CH:3]=1.S([O-])([O-])=O.[Na+].[Na+].C(O)=O>[OH-].[Na+]>[NH2:10][C:5]1[C:6]([SH:8])=[N:7][C:2]([Cl:1])=[CH:3][CH:4]=1参加物
5
実験手順
5-Chlorothiazolo[5,4-b]pyridin-2-amine (Q-2) (19 g, 103 mmol) containing sodium sulfite (2 g) was refluxed in 20% aqueous sodium hydroxide solution (150 mL) overnight. The solids were completely dissolved after 1 h, then cooled to room temperature. The solution was neutralized with formic acid. A precipitate was collected by filtration as the title compound (16.4 g).
後処理
- dissolutionThe solids were completely dissolved after 1 h
- filtrationA precipitate was collected by filtration as the title compound (16.4 g)
出典と根拠
- ORDレコード
- ord-0c0faf03469e4a188507d29fc1fbc16b
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987269B2
反応ノート
読み込み中…