Diethyl Ether → HCID 46261794、化合物

HRID 876903

反応式

HRID 876903 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([NH2:9])[CH:4]=1.Cl[C:11]1[N:16]=[C:15]([Cl:17])[N:14]=[C:13]2[N:18]([CH3:21])[N:19]=[CH:20][C:12]=12.C(N(CC)CC)C.CCOCC>C(O)C>[Cl:17][C:15]1[N:14]=[C:13]2[N:18]([CH3:21])[N:19]=[CH:20][C:12]2=[C:11]([NH:9][C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([O:2][CH3:1])[CH:4]=2)[N:16]=1

参加物

6

反応物 4

HCID 3283Diethyl EtherHCID 8471TriethylamineHCID 108243-MethoxyanilineHCID 2222474,6-dichloro-1-methyl-1H-pyrazolo(3,4-d)pyrimidine

生成物 1

HCID 46261794HCID 46261794、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

m-Anisidine (1.1 eq) was added to a solution of 4,6-dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine 5 (1 eq.) and triethylamine (NEt3, 1.5 eq) in ethanol. The mixture was stirred at room temperature for 2 hr and then ether was added. The solid was filtered off and the filtrate concentrated in vacuo to give 6-chloro-N-(3-methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 6.

後処理

  1. filtrationThe solid was filtered off
  2. concentrationthe filtrate concentrated in vacuo

出典と根拠

ORDレコード
ord-80e6685e623640debceec97824a5680b
出典データセット
uspto-grants-2015_03
特許番号
US08987280B2

関連ノート

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