Sodium Hydroxide → HCID 44513409、化合物

HRID 877270ノート

反応式

HRID 877270 の反応式
[CH3:1][CH:2]([CH2:40][CH3:41])[CH:3]([C:20]1[CH:25]=[CH:24][C:23]([CH2:26][N:27]2[C:32](=[O:33])[CH2:31][O:30][C:29]([C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=3)=[N:28]2)=[CH:22][CH:21]=1)[C:4]([NH:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH2:9][CH:10]([C:16]([O:18]C)=[O:17])[CH2:11]2)=[O:5].[OH-].[Na+]>C1COCC1>[CH3:1][CH:2]([CH2:40][CH3:41])[CH:3]([C:20]1[CH:25]=[CH:24][C:23]([CH2:26][N:27]2[C:32](=[O:33])[CH2:31][O:30][C:29]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][CH:39]=3)=[N:28]2)=[CH:22][CH:21]=1)[C:4]([NH:6][C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH2:9][CH:10]([C:16]([OH:18])=[O:17])[CH2:11]2)=[O:5]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 58136310HCID 58136310、化合物

生成物 1

HCID 44513409HCID 44513409、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 180 mg (0.31 mmol) of methyl 4-[(3-methyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}pentanoyl)amino]-2,3-dihydro-1H-indene-2-carboxylate (Example 147A) in 3.6 ml of THF and 1.3 ml (1.3 mmol) of 1 N aqueous sodium hydroxide solution was stirred at room temperature overnight. After the reaction had gone to completion, the THF was removed under reduced pressure and the reaction solution was diluted with water and then adjusted to pH 2 with 1 M hydrochloric acid. The precipitated solid was filtered off, washed with water and dried under reduced pressure at 45° C. overnight. This gave 159 mg (0.29 mmol, 91% of theory) of the title compound as a mixture of isomers.

後処理

  1. customthe THF was removed under reduced pressure
  2. additionthe reaction solution was diluted with water
  3. filtrationThe precipitated solid was filtered off
  4. washwashed with water
  5. customdried under reduced pressure at 45° C. overnight
  6. additionThis gave 159 mg (0.29 mmol, 91% of theory) of the title compound as a mixture of isomers

出典と根拠

ORDレコード
ord-506cd3df9af64af2991b691e4d02a149
出典データセット
uspto-grants-2015_03
特許番号
US08987256B2

反応ノート

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