Diisopropylethylamine → HCID 60197099、化合物

HRID 877969

反応式

HRID 877969 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5](Cl)=[O:6].[CH3:12][NH:13][C:14]1[CH:15]=[N:16][CH:17]=[CH:18][C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH3:26].CCN(C(C)C)C(C)C>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([N:13]([CH3:12])[C:14]1[CH:15]=[N:16][CH:17]=[CH:18][C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[CH3:26])=[O:6]

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 27365483-Chloro-4-fluorobenzoyl ChlorideHCID 18403336N-methyl-4-o-tolylpyridin-3-amine

生成物 1

HCID 60197099HCID 60197099、化合物収率 29%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

3-Chloro-4-fluorobenzoyl chloride (60 mg, 0.31 mmol, CAS RN 65055-17-6) was added to a solution of methyl-(4-o-tolyl-pyridin-3-yl)-amine (45 mg, 0.23 mmol, example 1, intermediate a) and DIPEA (79 μL, 0.45 mmol) in CH2Cl2 (1 mL). The reaction mixture was stirred overnight and then loaded directly onto a silica gel column and eluted with 50% EtOAc in n-hexane to yield the product as a waxy solid (23 mg, 29%). MS (ESI): m/z=355.0 [M+H]+.

後処理

  1. washeluted with 50% EtOAc in n-hexane

出典と根拠

ORDレコード
ord-3d1e2f56dcde4ff895a1a1fa88d547c7
出典データセット
uspto-grants-2015_03
特許番号
US08987307B2

関連ノート

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