4-Oxobutanoic acid → N-(3-carboxypropyl)-N-methyl-L-valyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(2S,3R)-1-(benzylamino)-3-hydroxy-1-oxobutan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide
反応式
F[C:2](F)(F)[C:3]([O-:5])=[O:4].[Na+].C(O[C:14]([N:16]([CH3:56])[C@H:17]([C:21]([NH:23][C@H:24]([C:28]([N:30]([C@@H:32]([C@@H:52]([CH3:55])[CH2:53][CH3:54])[C@H:33]([O:50][CH3:51])[CH2:34][C:35]([N:37]1[CH2:41][CH2:40][CH2:39][C@H:38]1[C@H:42]([O:48][CH3:49])[C@H:43]([C:45]([OH:47])=O)[CH3:44])=[O:36])[CH3:31])=[O:29])[CH:25]([CH3:27])[CH3:26])=[O:22])[CH:18]([CH3:20])[CH3:19])=O)(C)(C)C.F[C:58](F)(F)[C:59]([O-:61])=O.[Na+].[CH2:65]([NH:72][C:73](=[O:79])[C@H:74]([C@@H](C)O)[NH2:75])[C:66]1[CH:71]=[CH:70][CH:69]=[CH:68][CH:67]=1.N1(OC(N(C)C)=[N+](C)C)C2N=CC=C[C:83]=2N=N1.F[P-](F)(F)(F)(F)F.FC(F)(F)C(O)=O.O=CCCC(O)=O.C([BH3-])#N.[Na+]>>[C:3]([CH2:2][CH2:83][CH2:14][N:16]([CH3:56])[C@H:17]([C:21]([NH:23][C@H:24]([C:28]([N:30]([C@@H:32]([C@@H:52]([CH3:55])[CH2:53][CH3:54])[C@H:33]([O:50][CH3:51])[CH2:34][C:35]([N:37]1[CH2:41][CH2:40][CH2:39][C@H:38]1[C@H:42]([O:48][CH3:49])[C@@H:43]([CH3:44])[C:45]([NH:75][C@@H:74]([C@H:59]([OH:61])[CH3:58])[C:73]([NH:72][CH2:65][C:66]1[CH:71]=[CH:70][CH:69]=[CH:68][CH:67]=1)=[O:79])=[O:47])=[O:36])[CH3:31])=[O:29])[CH:25]([CH3:27])[CH3:26])=[O:22])[CH:18]([CH3:19])[CH3:20])([OH:5])=[O:4]参加物
7
反応物 6
HCID 11124-Oxobutanoic acid
HCID 6422Trifluoroacetic acid
HCID 5003444Sodium cyanoborohydride
HCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)
HCID 86698265N-(tert.-butoxycarbonyl)-N-methyl-L-valyl-N-[(3R,4 S,5S)-1-{(2S)-2-[(1R,2R)-2-carboxy-1-methoxypropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide sodium trifluoroacetate
