反応式
Cl[C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH2:10]([CH2:12][NH2:13])[OH:11].[OH-].[Na+]>O.O1CCOCC1>[CH3:8][C:6]1[CH:5]=[C:4]([CH3:9])[N:3]=[C:2]([O:11][CH2:10][CH2:12][NH2:13])[CH:7]=1参加物
6
実験手順
From 2-chloro-4,6-dimethylpyridine by treatment with ethanolamine and sodium hydroxide in a mixture of water and dioxane to afford 2-(4,6-dimethyl-pyridin-2-yloxy)-ethylamine, followed by heating with 1-fluoro-4-nitrobenzene in ethanol to give [2-(4,6-dimethyl-pyridin-2-yloxy)-ethyl]-(4-nitro-phenyl)-amine. The free amine is protected as a trifluoroacetamide by treatment with trifluoroacetic anhydride and sodium hydride in THF then the nitro group is reduced with zinc powder in the presence of ammonium chloride in ethanol. Following coupling with the appropriately-selected acid chloride, a final treatment with lithium hydroxide in methanol removes the trifluoroacetamide to give the final compound described.
出典と根拠
- ORDレコード
- ord-670e8ae524cb41b8b6ebd2e9f88f5142
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08993574B2
関連ノート
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