Acetic Acid → 4-Bromo-2-chloro-6-(trifluoromethyl)aniline

HRID 880655

反応式

HRID 880655 の反応式
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[C:11]=1[NH2:12].C(O)(=O)C>C(#N)C>[Br:1][C:15]1[CH:14]=[C:13]([C:17]([F:19])([F:18])[F:20])[C:11]([NH2:12])=[C:10]([Cl:9])[CH:16]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 67184N-bromobutanimideHCID 27563842-Chloro-6-(trifluoromethyl)aniline

生成物 1

HCID 162179374-Bromo-2-chloro-6-(trifluoromethyl)aniline

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

N-bromo succinimide (910 mg, 5.1 mmol) was added to a solution of 2-chloro-6-(trifluoromethyl)aniline (1.0 g, 5.1 mmol) and acetic acid (3 mL) in acetonitrile (10 mL) at room temperature. The mixture was heated at reflux, with stirring, for 18 h. The reaction mixture was then filtered through Celite and concentrated to give the title compound, which was used in the next step without further purification.

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux
  3. filtrationThe reaction mixture was then filtered through Celite
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-62cbed9771e744a78af50d42da7422b1
出典データセット
uspto-grants-2015_03
特許番号
US08993593B2

関連ノート

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