Hydrochloric Acid → (Z)-(1S,4R,6S,18R)-18-[2-(4-ethynyl-thiazol-2-yl)-7-methoxy-8-methyl-quinolin-4-yloxy]-13-methyl-2,14-dioxo-3,13,15-triaza-tricyclo[13.4.0.0*4,6*]nonadec-7-ene-4-carboxylic acid
反応式
C[O:2][C:3]([C@@:5]12[CH2:23][C@H:22]1[CH:21]=[CH:20][CH2:19][CH2:18][CH2:17][CH2:16][N:15]([CH3:24])[C:14](=[O:25])[N:13]1[C@@H:8]([CH2:9][C@H:10]([O:26][C:27]3[C:36]4[C:31](=[C:32]([CH3:39])[C:33]([O:37][CH3:38])=[CH:34][CH:35]=4)[N:30]=[C:29]([C:40]4[S:41][CH:42]=[C:43]([C:45]#[CH:46])[N:44]=4)[CH:28]=3)[CH2:11][CH2:12]1)[C:7](=[O:47])[NH:6]2)=[O:4].[Li+].[OH-].Cl>O1CCCC1.O>[C:45]([C:43]1[N:44]=[C:40]([C:29]2[CH:28]=[C:27]([O:26][C@H:10]3[CH2:9][C@@H:8]4[N:13]([C:14](=[O:25])[N:15]([CH3:24])[CH2:16][CH2:17][CH2:18][CH2:19][CH:20]=[CH:21][C@H:22]5[C@:5]([C:3]([OH:4])=[O:2])([NH:6][C:7]4=[O:47])[CH2:23]5)[CH2:12][CH2:11]3)[C:36]3[C:31](=[C:32]([CH3:39])[C:33]([O:37][CH3:38])=[CH:34][CH:35]=3)[N:30]=2)[S:41][CH:42]=1)#[CH:46]参加物
6
反応物 3
生成物 1
試薬・触媒・溶媒 2
実験手順
A mixture of compound 37 (0.11 g, 1 eq.) and LiOH (0.022 g, 5 eq.) in a mixture of tetrahydrofuran (5 mL) and water (5 mL) was stirred at room temperature overnight. HCl (1N) was added and the mixture was extracted with dichloromethane. Dried organics were evaporated in vacuo. The crude residue was purified by chromatography on silica gel to give compound 38 in 46% yield. MS (ESI, EI+) m/z=644 (MH+).
後処理
- extractionthe mixture was extracted with dichloromethane
- customDried organics were evaporated in vacuo
- customThe crude residue was purified by chromatography on silica gel
出典と根拠
- ORDレコード
- ord-ac3975ad8e9c4cc7887e74073da7a7fc
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08993595B2
反応ノート
読み込み中…