1,7-Diphenyl-4-heptanol → HCID 178418375、化合物

HRID 882

反応式

HRID 882 の反応式
[Si:1]([O:8][C@H:9]1[CH2:14][CH2:13][C@H:12](/[CH:15]=[C:16](\[CH3:19])/[CH:17]=[O:18])[CH2:11][CH2:10]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[C:20]1([CH2:26][CH2:27][CH2:28][Mg]Br)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C1(CCCC(O)CCCC2C=CC=CC=2)C=CC=CC=1>C1COCC1>[Si:1]([O:8][C@H:9]1[CH2:10][CH2:11][C@H:12](/[CH:15]=[C:16](\[CH3:19])/[CH:17]([OH:18])[CH2:28][CH2:27][CH2:26][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:13][CH2:14]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

参加物

5

反応物 3

HCID 105398701,7-Diphenyl-4-heptanolHCID 178418459HCID 178418459、化合物HCID 178418471HCID 178418471、化合物

生成物 1

HCID 178418375HCID 178418375、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The alcohol 137 was prepared from the crude aldehyde 136. and 1.5 mL (0.75 mmol) of 120 in 2.0 mL of THF as described above for the synthesis of alcohol 121 in Example 1 to give 220 mg of the crude diastereomeric alcohol 137. Flash chromatography (elution with 20% ethyl acetate in hexane) afforded 146 mg of the alcohol 137 as an oil. 1H NMR consistent with structure.

出典と根拠

ORDレコード
ord-a6be5895ebf2488a874923e3878acfbe
出典データセット
uspto-grants-1998_03
特許番号
US05723459

関連ノート

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