Thionyl Chloride → 3-Chloro-2-(chloromethyl)-4-methoxy-5-methylpyridine hydrochloride

HRID 882980ノート

反応式

HRID 882980 の反応式
[Cl:1][C:2]1[C:3]([CH2:11]O)=[N:4][CH:5]=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9].S(Cl)([Cl:15])=O>C(Cl)(Cl)Cl>[ClH:1].[Cl:1][C:2]1[C:3]([CH2:11][Cl:15])=[N:4][CH:5]=[C:6]([CH3:10])[C:7]=1[O:8][CH3:9]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 58201206HCID 58201206、化合物

生成物 1

HCID 666179323-Chloro-2-(chloromethyl)-4-methoxy-5-methylpyridine hydrochloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

The above (3-chloro-4-methoxy-5-methylpyridin-2-yl)methanol (530 mg) was dissolved in 20 ml of chloroform, and thionyl chloride (1.03 ml) was then added dropwise to the solution under cooling on ice. The resulting mixture was stirred at room temperature for 3 hours. Thereafter, the reaction solution was concentrated, and it was then washed with a mixed solvent of ether-hexane, so as to obtain the title compound (410 mg) as a solid.

後処理

  1. temperatureunder cooling on ice
  2. concentrationThereafter, the reaction solution was concentrated
  3. washit was then washed with a mixed solvent of ether-hexane

出典と根拠

ORDレコード
ord-41df0f954d0a441498005ea1e1d3eba0
出典データセット
uspto-grants-2012_08
特許番号
US08236813B2

反応ノート

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