反応式
[C:1](#[N:4])[CH:2]=C.[CH3:5][NH:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1>CO>[N:10]1[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=1[CH2:8][CH2:7][NH:6][CH2:5][CH2:2][C:1]#[N:4]参加物
4
反応条件
- 温度
- 20 °C
実験手順
Acrylonitrile (10.1 ml, 1.1 eq) is added slowly to a solution cooled down to approximately 4° C. of 2-[2-(methylamino)ethyl]pyridine (19.5 ml, 1 eq) in methanol (200 ml). The reaction medium is then stirred for 3 hours at approximately 20° C. then concentrated under reduced pressure at 40° C. in order to produce 3-[(2-pyridin-2-ylethyl)amino]propanenitrile in the form of a yellow oil (25.6 g, 96% yield).
後処理
- concentrationthen concentrated under reduced pressure at 40° C. in order
出典と根拠
- ORDレコード
- ord-a4d3af7ba3a6406e94241d5a9ad9a465
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08236965B2
関連ノート
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