Hydrochloric Acid → 7-methyl-8H-1,8-naphthyridin-4-one

HRID 883840

反応式

HRID 883840 の反応式
C(OC([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[N:10][C:11]([CH3:17])=[CH:12][CH:13]=2)[NH:8][CH:7]=1)=O)C.[OH-].[Na+].Cl>O>[CH3:17][C:11]1[N:10]=[C:9]2[C:14]([C:15]([OH:16])=[CH:6][CH:7]=[N:8]2)=[CH:13][CH:12]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 5373687Ethyl 7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate

生成物 1

HCID 1784229567-methyl-8H-1,8-naphthyridin-4-one収率 83%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of the product from Example 7b (1.30 g, 5.59 mmol) and NaOH (233 mg, 5.82 mmol) in 20 mL of water was heated in a sealed metal reactor at 180° C. for 16 h. Cooled to room temperature and adjusted to pH 6 with 1N HCl. The resulting precipitates was filtered and dried under vacuum giving the title compound as a black solid (743 mg, 82%).

後処理

  1. customThe resulting precipitates
  2. filtrationwas filtered
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-c385763234854722b8dd8f16ff9d8b7d
出典データセット
uspto-grants-2012_08
特許番号
US08236950B2

関連ノート

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