Methanol → 3-Amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl ester

HRID 883866ノート

反応式

HRID 883866 の反応式
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[C:6]([N+:19]([O-])=O)[CH:5]=1.[Cl-].[NH4+].CO.O1CCCC1>[Fe].O>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[CH:13][CH:12]=2)=[C:6]([NH2:19])[CH:5]=1

参加物

7

反応物 4

HCID 887MethanolHCID 8028TetrahydrofuranHCID 25517Ammonium ChlorideHCID 41664294-(4-Methoxy-phenylsulfanyl)-3-nitro-benzoic acid methyl ester

生成物 1

HCID 613055833-Amino-4-(4-methoxy-phenylsulfanyl)-benzoic acid methyl ester収率 90%

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 962Water溶媒

実験手順

To a solution of the product from Example 13A, iron powder and ammonium chloride in a methanol, tetrahydrofuran, and water solution was heated to reflux. The resultant mixture was filtered, and the filtrate was concentrated. Then ethyl acetate was added, stirred, filtered and concentrated to provide the title compound (7.16 g, 90%).

後処理

  1. filtrationThe resultant mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. additionThen ethyl acetate was added
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-b1f4d3b3ab3c4c358ded46292581f8db
出典データセット
uspto-grants-2012_08
特許番号
US08236950B2

反応ノート

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