Hydroxyamine hydrochloride → 2-((Hydroxyimino)methyl)-5-morpholin-4-yl-phenol

HRID 884435

反応式

HRID 884435 の反応式
[OH:1][C:2]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[NH2:17][OH:18]>N1C=CC=CC=1>[OH:18][N:17]=[CH:4][C:3]1[CH:6]=[CH:7][C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[CH:9][C:2]=1[OH:1]

参加物

4

反応物 2

HCID 443297Hydroxyamine hydrochlorideHCID 98156592-Hydroxy-4-morpholin-4-yl-benzaldehyde

生成物 1

HCID 1363488032-((Hydroxyimino)methyl)-5-morpholin-4-yl-phenol収率 35.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A solution of 2-hydroxy-4-morpholin-4-yl-benzaldehyde (0.135 g, 0.65 mmol) in pyridine (5 mL) was treated with hydroxylamine hydrochloride (45 mg, 0.65 mmol) and stirred for 30 min at room temperature. The reaction mixture was concentrated in vacuo and the residue was partitioned between EtOAc and 5% sodium bicarbonate. The organic layer was dried over Na2SO4 and concentrated in vacuo to afford the product as a pale yellow solid (51 mg, 35%).

後処理

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe residue was partitioned between EtOAc and 5% sodium bicarbonate
  3. dry with materialThe organic layer was dried over Na2SO4
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-6bfcad2636164749b890def519cc7420
出典データセット
uspto-grants-2012_08
特許番号
US08242115B2

関連ノート

読み込み中…