Ethyl chloroformate → HCID 68675322、化合物

HRID 889161ノート

反応式

HRID 889161 の反応式
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[IH:7].[CH3:8][N:9]1[CH2:13][CH2:12][N:11]=[C:10]1[NH:14][NH2:15]>N1C=CC=CC=1>[IH:7].[CH2:5]([O:4][C:2]([NH:15][NH:14][C:10]1[N:9]([CH3:8])[CH2:13][CH2:12][N:11]=1)=[O:3])[CH3:6]

参加物

4

反応物 2

HCID 10928Ethyl chloroformateHCID 2145886149541-82-4

生成物 1

HCID 68675322HCID 68675322、化合物

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Ethyl chloroformate (0.95 ml) was added dropwise to a mixture of (1-methyl-4,5-dihydro-1H-imidazol-2-yl)-hydrazine hydroiodide (CAS 49541-82-4) (2 g) and pyridine (40 ml) while stirring, and the mixture was stirred at room temperature for 2 hours. The solvent was distilled off and the residue was purified by silica gel column chromatography. The obtained compound was washed with diethyl ether to obtain the title compound (1.14 g).

後処理

  1. stirringthe mixture was stirred at room temperature for 2 hours
  2. distillationThe solvent was distilled off
  3. customthe residue was purified by silica gel column chromatography
  4. washThe obtained compound was washed with diethyl ether

出典と根拠

ORDレコード
ord-2e0b6e814d9f4028b7332515d872a272
出典データセット
uspto-grants-2012_08
特許番号
US08252810B2

反応ノート

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