Dimethylformamide → 4-Bromo-2,2-diphenylbutyric chloride

HRID 889871

反応式

HRID 889871 の反応式
[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5](O)=[O:6].S(Cl)([Cl:22])=O.CN(C)C=O>C(Cl)(Cl)Cl>[Br:1][CH2:2][CH2:3][C:4]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:5]([Cl:22])=[O:6]

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl Chloride2 回HCID 27569594-Bromo-2,2-diphenylbutyric acid

生成物 1

HCID 222500664-Bromo-2,2-diphenylbutyric chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

4-Bromo-2,2-diphenylbutyric acid (Compound B(1), 23 g, 72 mmol) was suspended in 150 mL of chloroform, and 20 mL of thionyl chloride (270 mmol) was added dropwise. After addition of the thionyl chloride, 0.2 mL of dimethylformamide was added and the resulting solution heated at reflux for about 4 h. The reaction mixture was then concentrated under reduced pressure to provide 4-bromo-2,2-diphenylbutyric chloride (Compound D(1)) as a pale yellow oil that was used in the following step without further purification.

後処理

  1. additionwas added
  2. temperaturethe resulting solution heated
  3. temperatureat reflux for about 4 h
  4. concentrationThe reaction mixture was then concentrated under reduced pressure

出典と根拠

ORDレコード
ord-b0821871a2314e6695b0528c5606f54e
出典データセット
uspto-grants-2006_02
特許番号
US06995168B2

関連ノート

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