1-Butanol → HCID 21933852、化合物

HRID 891423ノート

反応式

HRID 891423 の反応式
[CH2:1]([OH:5])[CH2:2][CH2:3][CH3:4].C[Si]([N-][Si](C)(C)C)(C)C.[Na+].[F:16][C:17]1[CH:18]=[C:19]([N:24]2[C:29](=[O:30])[C:28](Cl)=[C:27]([Cl:32])[CH:26]=[N:25]2)[CH:20]=[CH:21][C:22]=1[F:23]>C1COCC1>[F:16][C:17]1[CH:18]=[C:19]([N:24]2[C:29](=[O:30])[C:28]([O:5][CH2:1][CH2:2][CH2:3][CH3:4])=[C:27]([Cl:32])[CH:26]=[N:25]2)[CH:20]=[CH:21][C:22]=1[F:23]

参加物

5

反応物 3

HCID 2631-ButanolHCID 2724254Sodium bis(trimethylsilyl)amideHCID 219343084,5-Dichloro-2-(3,4-difluorophenyl)pyridazin-3(2H)-one

生成物 1

HCID 21933852HCID 21933852、化合物収率 79.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒3 回

実験手順

To a stirred, room temperature solution of n-butanol (0.81 g, 10.93 mmol, 1.1 equiv.) in THF (20 mL) was slowly added 1.0 M sodium bis(trimethylsilyl)amide in THF (12 mL, 12 mmol, 1.2 equiv.). The reaction mixture was stirred for 0.5 hours, then it was transferred to a solution of 2-(3,4-difluorophenyl)-4,5-dichloro-3(2H)-pyridazinone (2.88 g, 10.4 mmol, 1.0 equiv.) in THF (80 mL). The resulting reaction mixture was stirred for 0.5 hours at room temperature to provide the title compound (2.5 g, 79.4%).

後処理

  1. customThe resulting reaction mixture
  2. stirringwas stirred for 0.5 hours at room temperature

出典と根拠

ORDレコード
ord-45a10491ab8a4933a9bd8b642cc1c1ba
出典データセット
uspto-grants-2006_02
特許番号
US07001895B2

反応ノート

読み込み中…