N-(5-Nitro-2-methoxyphenyl)-2,2,5-trimethyl-beta-oxo-1,3-dioxane-5-propanamide → N-(5-AMINO-2-METHOXYPHENYL)-2,2,5-TRIMETHYL-beta-OXO-1,3-DIOXANE-5-PROPANAMIDE

HRID 892404ノート

反応式

HRID 892404 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:25][CH3:26])=[C:8]([NH:10][C:11](=[O:24])[CH2:12][C:13](=[O:23])[C:14]2([CH3:22])[CH2:19][O:18][C:17]([CH3:21])([CH3:20])[O:16][CH2:15]2)[CH:9]=1)([O-])=O>O1CCCC1.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:25][CH3:26])=[C:8]([NH:10][C:11](=[O:24])[CH2:12][C:13](=[O:23])[C:14]2([CH3:22])[CH2:19][O:18][C:17]([CH3:20])([CH3:21])[O:16][CH2:15]2)[CH:9]=1

参加物

4

反応物 1

HCID 19895265N-(5-Nitro-2-methoxyphenyl)-2,2,5-trimethyl-beta-oxo-1,3-dioxane-5-propanamide

生成物 1

HCID 53685390N-(5-AMINO-2-METHOXYPHENYL)-2,2,5-TRIMETHYL-beta-OXO-1,3-DIOXANE-5-PROPANAMIDE

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

N-(5-Nitro-2-methoxyphenyl)-2,2,5-trimethyl-β-oxo-1,3-dioxane-5-propanamide (22parts) are dissolved in dry tetrahydrofuran (250 parts) and placed in a Parr bottle. The nitro compound is hydrogenated at low pressure and at ambient conditions in a Parr apparatus over Pd-C catalyst (2.5 parts) for 3.5 hr. Thin layer chromatography is used to monitor reaction completion which appears to be quantitative with no other products except the desired amine. The reaction product is carried to the next synthesis without purification other than filtration to remove spent catalyst.

後処理

  1. customreaction completion which
  2. customThe reaction product is carried to the next synthesis without purification other than filtration
  3. customto remove

出典と根拠

ORDレコード
ord-a80eaf050afc47a69fda9c2e28a7b3ba
出典データセット
uspto-grants-1992_06
特許番号
US05118599

反応ノート

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