Tetrahydrofuran → 6,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylic Acid

HRID 894200

反応式

HRID 894200 の反応式
[OH:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]([O:19]C)=[O:18])=[CH:16][C:3]1=2.O1CCCC1.[OH-].[Na+]>O>[OH:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]([OH:19])=[O:18])=[CH:16][C:3]1=2

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 2769059Methyl 11-hydroxy-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate

生成物 1

HCID 129291446,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylic Acid

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Dissolve 900 mg. of methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate in 20 cc. of tetrahydrofuran. Add 20 cc. 1 N aqueous sodium hydroxide. Stir at room temperature for 48 hours. Dilute with water and extract with ether. Acidify the aqueous fraction with hydrochloric acid and extract with ether. Evaporate the organic phase to obtain the title product (m.p. 275° C. dec.).

後処理

  1. dissolutionDissolve 900 mg
  2. additionAdd 20 cc
  3. extractionextract with ether
  4. extractionextract with ether
  5. customEvaporate the organic phase

出典と根拠

ORDレコード
ord-06261300041049b7ae1e5f982962a19a
出典データセット
uspto-grants-1981_08
特許番号
US04282365

関連ノート

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