Piperidine → N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide

HRID 895476

反応式

HRID 895476 の反応式
Br[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[C:10]([Cl:12])[N:9]=[C:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:7]=1)=[O:4].[NH:19]1[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>C(#N)C>[Cl:12][C:10]1[N:9]=[C:8]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:7]=[C:6]([NH:5][C:3](=[O:4])[CH2:2][N:19]2[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH:11]=1

参加物

4

反応物 2

HCID 8082PiperidineHCID 223791512-bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide

生成物 1

HCID 22353518N-(6-chloro-2-phenylpyrimidin-4-yl)-2-piperidin-1-ylacetamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒2 回

実験手順

2-Bromo-N-(6-chloro-2-phenylpyrimidin-4-yl)acetamide (28 mg) was dissolved in acetonitrile (2 ml) and piperidine added (23 μl in 500 ul acetonitrile). The mixture was left to stir for 1.5 hr after which time the solvent was removed in vacuo. Purification using a short silica plug, eluting with a mixture of ethyl acetate and petroleum ether (1:1 v/v) furnished the title compound (25 mg).

後処理

  1. waitThe mixture was left
  2. customwas removed in vacuo
  3. customPurification
  4. washeluting with a mixture of ethyl acetate and petroleum ether (1:1 v/v)

出典と根拠

ORDレコード
ord-ad95920473d8498281b9e63a8038cdd2
出典データセット
uspto-grants-2005_07
特許番号
US06916804B2

関連ノート

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