Hydrochloric Acid → 2-Amino-N-cyclopropylbenzenesulfonamide

HRID 896349

反応式

HRID 896349 の反応式
[CH:1]1([NH:4][S:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[N+:14]([O-])=O)(=[O:7])=[O:6])[CH2:3][CH2:2]1.Cl>CCO.[Pd]>[NH2:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[S:5]([NH:4][CH:1]1[CH2:3][CH2:2]1)(=[O:7])=[O:6]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 796630N-cyclopropyl-2-nitrobenzenesulfonamide

生成物 1

HCID 167933782-Amino-N-cyclopropylbenzenesulfonamide収率 98.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of N-cyclopropyl-2-nitro-benzenesulfonamide (7.9 g, 33.0 mmol) in EtOH (50 ml) was treated with HCl (3.0 ml, 4.0 N in dioxane), Pd/C (10%, 100 mg) and shaken in a Parr Hydrogenator at 50 psi for 48 h. The catalyst was removed by filtration and the solvent evaporated to give 6.9 g (84%) of 2-Amino-N-cyclopropyl-benzenesulfonamide as a light grey solid.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe solvent evaporated

出典と根拠

ORDレコード
ord-11c07d3686654430a629bd130ea97501
出典データセット
uspto-grants-2005_07
特許番号
US06919331B2

関連ノート

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