Tetrahydrofuran → Ethyl 3-phenyl-5-trimethylsilanylpent-2-en-4-ynoate

HRID 897067

反応式

HRID 897067 の反応式
[C:1]1([C:7]#[C:8][C:9]([O:11][CH3:12])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:13][Si:14]([CH3:18])([CH3:17])[C:15]#[CH:16].[CH2:19]1COCC1>C([O-])(=O)C.[Pd+2].C([O-])(=O)C>[C:1]1([C:7]([C:16]#[C:15][Si:14]([CH3:18])([CH3:17])[CH3:13])=[CH:8][C:9]([O:11][CH2:12][CH3:19])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 66111TrimethylsilylacetyleneHCID 138378Phenylpropynoic acid methyl ester

生成物 1

HCID 86142661Ethyl 3-phenyl-5-trimethylsilanylpent-2-en-4-ynoate

試薬・触媒・溶媒 1

HCID 167845palladium(II) acetate触媒

実験手順

A solution of TDMPP (1.4 g) and palladium acetate (700 mg) in THF (200 ml) is stirred for 15 min at room temperature and methyl phenylpropiolate (10 g, 62.5 mmol) is then added. The reaction medium is stirred for 5 min at room temperature and trimethyl-silylacetylene (87.5 mmol) is then added. Stirring is continued overnight at room temperature. The reaction medium is concentrated and filtered through silica.

後処理

  1. stirringStirring
  2. waitis continued overnight at room temperature
  3. concentrationThe reaction medium is concentrated
  4. filtrationfiltered through silica

出典と根拠

ORDレコード
ord-61eae75c5d7947aeb1d138ab049b4db4
出典データセット
uspto-grants-2005_07
特許番号
US06921777B2

関連ノート

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