Piperazine → n,n'-Bis-((e)-3-(2-methoxyphenyl)-2-propenyl)piperazine

反応式

[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1[CH:5]=[CH:6][CH2:7]O.S(Cl)(Cl)=O.[NH:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1>>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=1/[CH:5]=[CH:6]/[CH2:7][N:17]1[CH2:22][CH2:21][N:20]([CH2:7]/[CH:6]=[CH:5]/[C:4]2[CH:9]=[CH:10][CH:11]=[CH:12][C:3]=2[O:2][CH3:1])[CH2:19][CH2:18]1

参加物

反応物 3

HCID 4837Piperazine

HCID 24386Thionyl Chloride

HCID 534016582-Methoxy-cinnamylalcohol

生成物 1

HCID 19694161n,n'-Bis-((e)-3-(2-methoxyphenyl)-2-propenyl)piperazine

実験手順

2-Methoxy-cinnamylalcohol (1.44 g) was chlorinated using thionylchloride. Subsequently, reaction with piperazine and other treatments were performed as described in Preparation Example 2, to thereby obtain 314 mg of a salt as colorless prisms.