3,4-Dihydroxybenzaldehyde → 4-Hydroxy-3-propoxybenzaldehyde
反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[OH:10])[CH:5]=[O:6].[H-].[Na+].I[CH2:14][CH2:15][CH3:16]>CN(C=O)C.C(OCC)(=O)C>[OH:10][C:9]1[CH:8]=[CH:7][C:4]([CH:5]=[O:6])=[CH:3][C:2]=1[O:1][CH2:14][CH2:15][CH3:16]参加物
6
実験手順
3,4-Dihydroxybenzaldehyde (0.5 g, 3.62 mmol) was dissolved in DMF (10 mL) and sodium hydride (0.087 g, 3.62 mmol) was added. The reaction mixture was stirred at rt for 10 min. Iodopropane (0.35 mL, 0.62 mmol) was added and the reaction was stirred at 80° C. for 2.5 h. The reaction was diluted with ethyl acetate and washed with 2N HCl and water. Silica gel chromatography eluting with 35% ethyl acetate/hexane yielded 0.16 g of desired product: ESI-MS 181 (M+H).
後処理
- stirringthe reaction was stirred at 80° C. for 2.5 h
- washwashed with 2N HCl and water
- washSilica gel chromatography eluting with 35% ethyl acetate/hexane
出典と根拠
- ORDレコード
- ord-cbab7b2cf3c546d3a9c078fecfbbfae0
- 出典データセット
- uspto-grants-2008_04
- 特許番号
- US07351725B2
反応ノート
読み込み中…