Potassium Carbonate → 1-(2-Chloro-4-nitro-benzyl)-pyrrolidine

HRID 898586ノート

反応式

HRID 898586 の反応式
C(=O)([O-])[O-].[K+].[K+].Br[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][C:10]=1[Cl:18].[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>C(#N)C.ClCCl>[Cl:18][C:10]1[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:9]=1[CH2:8][N:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 30163681-(Bromomethyl)-2-chloro-4-nitrobenzene

生成物 1

HCID 576632361-(2-Chloro-4-nitro-benzyl)-pyrrolidine

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒HCID 6344Dichloromethane溶媒

実験手順

10.50 g (74.452 mmol) potassium carbonate was added to a solution of 7.400 g (29.543 mmol) of 1-bromomethyl-2-chloro-4-nitro-benzene and 5.00 mL (59.300 mmol) pyrrolidine in 150 mL acetonitrile and the mixture was stirred for 16 h at RT. The reaction mixture was diluted with 200 mL dichloromethane, filtered and the filtrate evaporated down i. vac. The residue was taken up in EtOAc, the org. phase was washed with water, dried over magnesium sulphate and evaporated down i. vac. The crude product was used in the next reaction step without any further purification.

後処理

  1. filtrationfiltered
  2. customthe filtrate evaporated down i
  3. washphase was washed with water
  4. dry with materialdried over magnesium sulphate
  5. customevaporated down i
  6. customThe crude product was used in the next reaction step without any further purification

出典と根拠

ORDレコード
ord-c84acf0f55b54d35ba4b0b73163d9c1b
出典データセット
uspto-grants-2008_04
特許番号
US07351719B2

反応ノート

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