Water → Perindopril erbumine monohydrate

HRID 898742

反応式

HRID 898742 の反応式
[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]>C(#N)C>[CH3:1][CH2:2][CH2:3][C@H:4]([NH:10][C@H:11]([C:13]([N:15]1[C@H:23]([C:24]([OH:26])=[O:25])[CH2:22][C@H:21]2[C@@H:16]1[CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:14])[CH3:12])[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH3:27][C:28]([NH2:31])([CH3:30])[CH3:29].[OH2:32]

参加物

4

反応物 2

HCID 962WaterHCID 441313Perindopril Erbumine

生成物 1

HCID 9847044Perindopril erbumine monohydrate

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Perindopril erbumine (5 gms) was suspended in acetonitrile (75 ml). To this was added water (0.4 ml) and the contents heated to dissolve the solids and cooled to 0 EC. The resulting slurry was filtered to obtain perindopril erbumine monohydrate (2.9 gms).

後処理

  1. temperaturethe contents heated
  2. dissolutionto dissolve the solids
  3. temperaturecooled to 0 EC
  4. filtrationThe resulting slurry was filtered

出典と根拠

ORDレコード
ord-5a42d62a17dd43a8b107ff4b4ae0b469
出典データセット
uspto-grants-2008_04
特許番号
US07351840B2

関連ノート

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