N-Iodosuccinimide → HCID 178470396、化合物

HRID 900233ノート

反応式

HRID 900233 の反応式
[CH2:1]([O:3][C:4]([C:6]1[NH:7][CH:8]=[N:9][C:10]=1[CH3:11])=[O:5])[CH3:2].C1C(=O)N([I:19])C(=O)C1>C1COCC1>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]([I:19])=[N:9][C:10]=1[CH3:11])=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 120273N-IodosuccinimideHCID 178470400HCID 178470400、化合物

生成物 1

HCID 178470396HCID 178470396、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 5 g 5-Methyl-3H-imidazole-4-carboxylic acid ethyl ester and 7.2 g NIS in 50 ml THF were refluxed for 10 h. After cooling, the solvent was removed under reduced pressure and the residue taken-up in ethyl acetate, washed with sat. NaS2O3 solution and dried over MgSO4. After removal of the solvent under reduced pressure the product was purified by recrystallisation from ethyl acetate. Yield: 7 g

後処理

  1. temperatureAfter cooling
  2. customthe solvent was removed under reduced pressure
  3. washthe residue taken-up in ethyl acetate, washed with sat. NaS2O3 solution
  4. dry with materialdried over MgSO4
  5. customAfter removal of the solvent under reduced pressure the product
  6. customwas purified by recrystallisation from ethyl acetate

出典と根拠

ORDレコード
ord-cc9326ec9b034b019e7134ef7508ca68
出典データセット
uspto-grants-2008_04
特許番号
US07358268B2

反応ノート

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