HCID 9834575、化合物 → HCID 9833987、化合物

HRID 900494ノート

反応式

HRID 900494 の反応式
C([O:8][CH2:9][CH2:10][C@H:11]([OH:17])[C:12]([CH3:16])([CH3:15])[C:13]#[N:14])C1C=CC=CC=1>[OH-].[OH-].[Pd+2].O1CCCC1>[OH:8][CH2:9][CH2:10][C@H:11]([OH:17])[C:12]([CH3:16])([CH3:15])[C:13]#[N:14]

参加物

4

反応物 1

HCID 9834575HCID 9834575、化合物2 回

生成物 1

HCID 9833987HCID 9833987、化合物

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 8028Tetrahydrofuran溶媒

実験手順

16 g of Pearlman's catalyst (Pd(OH)2 on carbon, 20%) is added to 11.13 g (47.70 mmol) of 5-benzyloxy-2,2-dimethyl-3 (S)-hydroxy-pentane-nitrile of the title compound of Example 1c, dissolved in 110 ml of tetrahydrofuran. It is now hydrogenated for 7.5 hours at 10 bar and at room temperature. Catalyst is filtered out, and the filtrate is evaporated to the dry state in a vacuum.

後処理

  1. filtrationCatalyst is filtered out
  2. customthe filtrate is evaporated to the dry state in a vacuum

出典と根拠

ORDレコード
ord-ba0305cad14747088b0e684d6cfff784
出典データセット
uspto-grants-2008_04
特許番号
US07358382B2

反応ノート

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