Water → 1-Azido-3-acetoxyacetone

HRID 903194

反応式

HRID 903194 の反応式
Cl[CH2:2][C:3]([CH2:5][O:6][C:7](=[O:9])[CH3:8])=[O:4].O.[N-:11]=[N+:12]=[N-:13].[Na+]>O1CCCC1.CCOCC>[N:11]([CH2:2][C:3]([CH2:5][O:6][C:7](=[O:9])[CH3:8])=[O:4])=[N+:12]=[N-:13]

参加物

6

反応物 3

HCID 962WaterHCID 33557Sodium AzideHCID 384132-Propanone, 1-(acetyloxy)-3-chloro-

生成物 1

HCID 144347801-Azido-3-acetoxyacetone

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

1-Chloro-3-acetoxyacetone (15.05 g.) is dissolved in tetrahydrofuran (50 ml.) and water (25 ml.) is added. Sodium azide (8.7 g.) is added and the mixture is allowed to stir overnight at room temperature. The reaction mixture is diluted with ether (200 ml.) and the aqueous phase is separated. The organic phase is washed once with brine, then dried and evaporated to give 1-azido-3-acetoxyacetone.

後処理

  1. customthe aqueous phase is separated
  2. washThe organic phase is washed once with brine
  3. customdried
  4. customevaporated

出典と根拠

ORDレコード
ord-cbfc365275df4b84be1e1ffe5a583ae4
出典データセット
uspto-grants-1980_10
特許番号
US04226866

関連ノート

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