2-Oxobutanoic Acid → Thiazolidinecarboxylic acid, 2-ethyl-

HRID 903887

反応式

HRID 903887 の反応式
Cl.[NH2:2][CH2:3][CH2:4][SH:5].C(N(CC)CC)C.O=[C:14]([CH2:18][CH3:19])[C:15]([OH:17])=[O:16]>C(O)C>[CH2:18]([C:14]1([C:15]([OH:17])=[O:16])[NH:2][CH2:3][CH2:4][S:5]1)[CH3:19]

参加物

5

反応物 3

HCID 582-Oxobutanoic AcidHCID 8471TriethylamineHCID 9082Cysteamine Hydrochloride

生成物 1

HCID 198462Thiazolidinecarboxylic acid, 2-ethyl-収率 65.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

11.4 g of cysteamine hydrochloride and 10.1 g of triethylamine were dissolved in 100 ml of ethanol, to which was added 10.2 g of 2-keto-butyric acid. The mixture was refluxed for 30 minutes, cooled and filtered thereby giving 10.6 g (yield 65.7%) of 2-ethyl-thiazolidine-2-carboxylic acid with a melting point of 235°-238° C. (decomposed).

後処理

  1. temperatureThe mixture was refluxed for 30 minutes
  2. temperaturecooled
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-6417e3b5d0cb4c31933f5935b2dc8ca2
出典データセット
uspto-grants-1980_10
特許番号
US04229461

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