Nitric Acid → 4-Acetamido-3-nitrobenzophenone

HRID 904354

反応式

HRID 904354 の反応式
[C:1]([NH:4][C:5]1[CH:18]=[CH:17][C:8]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[O:10])=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(OC(=O)C)(=O)C.[N+:26]([O-])([OH:28])=[O:27].NC(N)=O.C(C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(O)(=O)C>[C:1]([NH:4][C:5]1[CH:18]=[CH:17][C:8]([C:9]([C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:10])=[CH:7][C:6]=1[N+:26]([O-:28])=[O:27])(=[O:3])[CH3:2]

参加物

7

反応物 5

HCID 944Nitric AcidHCID 1176UreaHCID 3102BenzophenoneHCID 7918Acetic AnhydrideHCID 228532N-(4-benzoylphenyl)acetamide

生成物 1

HCID 5969694-Acetamido-3-nitrobenzophenone収率 62.5%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

反応条件

温度
50 °C

実験手順

Twenty-three grams (0.1 mole) of 4-acetamidobenzophenone, 50 ml. of acetic anhydride and 20 ml. of acetic acid were stirred together. A solution of 90 percent nitric acid (15 ml.), 10 ml. of acetic acid and 0.2 g. of urea was added dropwise to the benzophenone mixture. The reaction mixture was maintained at a temperature of about 50° C. during the nitration. The mixture was stirred at ambient temperature whereupon the mixture became very thick. The thick slurry was poured over ice and the insoluble product was filtered to yield 17.7 g. (62.5 percent yield) of 4-acetamido-3-nitrobenzophenone.

後処理

  1. additionThe thick slurry was poured over ice
  2. filtrationthe insoluble product was filtered
  3. customto yield 17.7 g

出典と根拠

ORDレコード
ord-06d3d4d055dd431abcb653224e04381a
出典データセット
uspto-grants-1980_10
特許番号
US04230868

関連ノート

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