Water → 4-Bromo-1-(bromomethyl)-2-chlorobenzene

HRID 906492

反応式

HRID 906492 の反応式
[Cl:1][C:2]1[CH:7]=[C:6]([Br:8])[CH:5]=[CH:4][C:3]=1[CH3:9].C1C(=O)N([Br:17])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C.O>C(Cl)(Cl)(Cl)Cl>[Br:8][C:6]1[CH:5]=[CH:4][C:3]([CH2:9][Br:17])=[C:2]([Cl:1])[CH:7]=1

参加物

6

反応物 4

HCID 962WaterHCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 27355544-Bromo-2-chlorotoluene

生成物 1

HCID 219144864-Bromo-1-(bromomethyl)-2-chlorobenzene収率 55.3%

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

5.0 g of 2-chloro-4-bromotoluene are dissolved in 120 ml of CCl4. 4.3 g of NBS and 1.6 g of AIBN are added. The mixture is heated at reflux for 15 hours, water is added, the two phases are separated and then extraction is carried out with CH2Cl2. Purification is carried out by chromatography on a silica column eluted with petroleum ether. 3.8 g of liquid are obtained.

後処理

  1. temperatureThe mixture is heated
  2. temperatureat reflux for 15 hours
  3. customthe two phases are separated
  4. extractionextraction
  5. customPurification
  6. washeluted with petroleum ether

出典と根拠

ORDレコード
ord-1d17187996294ba3befa45d30c8cc81c
出典データセット
uspto-grants-2011_09
特許番号
US08012991B2

関連ノート

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