Dimethylamine → Dimethyl-[(2-methyl-1H-indol-3-yl)-p-tolyl-methyl]-amine

反応式

[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.[Cl-].[CH3:12][C:13]1[CH:22]=[CH:21][C:16]([CH:17]=[N+:18]([CH3:20])[CH3:19])=[CH:15][CH:14]=1.CC1C=CC(C=O)=CC=1.CNC>>[CH3:19][N:18]([CH3:20])[CH:17]([C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[NH:3][C:2]=1[CH3:1])[C:16]1[CH:21]=[CH:22][C:13]([CH3:12])=[CH:14][CH:15]=1

参加物

反応物 4

HCID 674Dimethylamine

HCID 72242-Methylindole

HCID 77254-Methylbenzaldehyde

HCID 13930190N,N-Dimethyl(4-methylphenyl)methaniminium chloride

生成物 1

HCID 21985344Dimethyl-[(2-methyl-1H-indol-3-yl)-p-tolyl-methyl]-amine

実験手順

The preparation was carried out in accordance with general synthesis instructions 4 from 2-methyl-1H-indole and (4-methyl-benzylidene)-dimethylammonium chloride, which had been prepared in accordance with example 44 from 4-methyl-benzaldehyde and dimethylamine.