Hydrochloric Acid → HCID 58446922、化合物

HRID 908231ノート

反応式

HRID 908231 の反応式
[OH-].[Na+].C([O:5][C:6]([C:8]1[N:9]([CH3:19])[N:10]=[CH:11][C:12]=1[C:13]([N:15]1[CH2:18][CH2:17][CH2:16]1)=[O:14])=[O:7])C.Cl.[Na+].[Cl-]>C1COCC1>[N:15]1([C:13]([C:12]2[CH:11]=[N:10][N:9]([CH3:19])[C:8]=2[C:6]([OH:7])=[O:5])=[O:14])[CH2:18][CH2:17][CH2:16]1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 5234Sodium ChlorideHCID 14798Sodium HydroxideHCID 67041800ethyl 4-(azetidine-1-carbonyl)-1-methyl-1H-pyrazole-5-carboxylate

生成物 1

HCID 58446922HCID 58446922、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

NaOH (1N, 10 ml) was added to a solution of 4-(azetidine-1-carbonyl)-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester (1.32 g, 5.0 mmol) in THF (50 ml), and the mixture was stirred at r.t. (3.5 h). The mixture was neutralized by addition of HCl (1N, 10 ml). The mixture was evaporated under vacuum and the title compound, containing theoretically 2 equiv. of NaCl, (1.72 g, 99%) was used in Step 6 without further purification. MS (m/e)=210.2 [M+H+].

後処理

  1. customThe mixture was evaporated under vacuum

出典と根拠

ORDレコード
ord-8549ca19a572413c87c2426f9bcb4212
出典データセット
uspto-grants-2011_09
特許番号
US08017604B2

反応ノート

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