Water → 2-Phenylimidazo[1,2-c]pyrimidin-7-amine

HRID 908236

反応式

HRID 908236 の反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=O.C([O-])(O)=O.[Na+].[NH2:16][C:17]1[CH:22]=[C:21]([NH2:23])[N:20]=[CH:19][N:18]=1.O>CO>[C:5]1([C:3]2[N:16]=[C:17]3[CH:22]=[C:21]([NH2:23])[N:20]=[CH:19][N:18]3[CH:2]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

6

反応物 4

HCID 962WaterHCID 6259Phenacyl bromideHCID 79608Pyrimidine-4,6-diamineHCID 516892Sodium Bicarbonate

生成物 1

HCID 4040512-Phenylimidazo[1,2-c]pyrimidin-7-amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

ω-Bromoacetophenone (9.04 g, 45 mmol) and NaHCO3 (4.30 g, 50 mmol) were added to a solution of 4,6-diaminopyrimidine (5.00 g, 0.45 mmol) in methanol (80 ml), and the mixture was heated to reflux (3 h). Upon cooling, water (40 ml) was added, and the suspension was stirred at r.t. (15 min). The precipitated title compound (5.62 g, 59%) was isolated by filtration, washed with small amounts of water and methanol, and dried under vacuum. MS (m/e)=211.1 [M+H+].

後処理

  1. temperaturethe mixture was heated
  2. temperatureto reflux (3 h)
  3. temperatureUpon cooling
  4. customThe precipitated title compound (5.62 g, 59%)
  5. customwas isolated by filtration
  6. washwashed with small amounts of water and methanol
  7. customdried under vacuum

出典と根拠

ORDレコード
ord-977e643049e748a8ae969dd88ddb423f
出典データセット
uspto-grants-2011_09
特許番号
US08017604B2

関連ノート

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