Hydrochloric Acid → 2-(7-(3,5-Dimethylisoxazol-4-yl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid

HRID 908569ノート

反応式

HRID 908569 の反応式
[CH3:1][C:2]1[C:6]([C:7]2[CH:16]=[C:15]3[C:10]([C:11]([OH:27])=[C:12]([C:19]([NH:21][CH2:22][C:23]([O:25]C)=[O:24])=[O:20])[C:13](=[O:18])[N:14]3[CH3:17])=[CH:9][CH:8]=2)=[C:5]([CH3:28])[O:4][N:3]=1.[OH-].[Na+].Cl>CO.C1COCC1>[CH3:1][C:2]1[C:6]([C:7]2[CH:16]=[C:15]3[C:10]([C:11]([OH:27])=[C:12]([C:19]([NH:21][CH2:22][C:23]([OH:25])=[O:24])=[O:20])[C:13](=[O:18])[N:14]3[CH3:17])=[CH:9][CH:8]=2)=[C:5]([CH3:28])[O:4][N:3]=1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 59340101HCID 59340101、化合物

生成物 1

HCID 593400822-(7-(3,5-Dimethylisoxazol-4-yl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetic acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
24 °C

実験手順

Suspended Methyl 2-(7-(3,5-dimethylisoxazol-4-yl)-4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carboxamido)acetate in 3 ml MeOH, 1 ml THF, and 2 ml 1M aqueous NaOH and stirred at 24° C. for 4 hours. The mixture was acidified to pH=1 using 2M aqueous HCl and the solids collected by filtration, washed with H2O and dried in vacuo: 50 mg white solids.

後処理

  1. filtrationthe solids collected by filtration
  2. washwashed with H2O
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-2c41a1adf70b4e409c52b122d4d859f0
出典データセット
uspto-grants-2011_09
特許番号
US08017626B2

反応ノート

読み込み中…