Hydrochloric Acid → (R)-3-(4-isopropyl-benzylcarbamoyl)-4-(4-trifluoromethyl-benzenesulfonyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl-5'-carboxylic acid

To a mixed solution of the compound (75 mg) obtained in Example 8 in tetrahydrofuran (400 μl) and methanol (400 μl) was added, with stirring at room temperature, 2N aqueous sodium hydroxide solution (186 μl). After stirring at room temperature for 30 min, 2N aqueous hydrochloric acid solution (186 μl) was added, and the mixture was concentrated under reduced pressure. Methanol and water were added to the residue, and the mixture was stirred at room temperature. The precipitated crystals were collected by filtration, and dried to give the title compound (61 mg).

1. stirringAfter stirring at room temperature for 30 min
2. concentrationthe mixture was concentrated under reduced pressure
3. additionMethanol and water were added to the residue
4. stirringthe mixture was stirred at room temperature
5. filtrationThe precipitated crystals were collected by filtration
6. customdried

ORDレコード

ord-d6743426456f4c32bdecbd9493c750c7

出典データセット

uspto-grants-2011_09

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08017612B2