Diisopropylethylamine → (R)-4-(7-chloro-5-trifluoromethyl-thiazolo[4,5-d]pyrimidin-2-yl)-1-(4-cyclopropyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-trifluoromethoxy-benzylamide

反応式

Cl[C:2]1[S:3][C:4]2[C:9]([Cl:10])=[N:8][C:7]([C:11]([F:14])([F:13])[F:12])=[N:6][C:5]=2[N:15]=1.[F:16][C:17]([F:48])([F:47])[O:18][C:19]1[CH:46]=[CH:45][C:22]([CH2:23][NH:24][C:25]([C@H:27]2[CH2:32][NH:31][CH2:30][CH2:29][N:28]2[S:33]([C:36]2[CH:41]=[CH:40][C:39]([CH:42]3[CH2:44][CH2:43]3)=[CH:38][CH:37]=2)(=[O:35])=[O:34])=[O:26])=[CH:21][CH:20]=1.C(N(CC)C(C)C)(C)C>C(Cl)(Cl)Cl>[F:48][C:17]([F:16])([F:47])[O:18][C:19]1[CH:46]=[CH:45][C:22]([CH2:23][NH:24][C:25]([C@H:27]2[CH2:32][N:31]([C:2]3[S:3][C:4]4[C:9]([Cl:10])=[N:8][C:7]([C:11]([F:14])([F:13])[F:12])=[N:6][C:5]=4[N:15]=3)[CH2:30][CH2:29][N:28]2[S:33]([C:36]2[CH:41]=[CH:40][C:39]([CH:42]3[CH2:43][CH2:44]3)=[CH:38][CH:37]=2)(=[O:34])=[O:35])=[O:26])=[CH:21][CH:20]=1