Diisopropylethylamine → (R)-4-(7-chloro-5-cyclopropyl-thiazolo[4,5-d]pyrimidin-2-yl)-1-(4-cyclopropyl-benzenesulfonyl)-piperazine-2-carboxylic acid 4-trifluoromethoxy-benzylamide

反応式

[F:1][C:2]([F:33])([F:32])[O:3][C:4]1[CH:31]=[CH:30][C:7]([CH2:8][NH:9][C:10]([C@H:12]2[CH2:17][NH:16][CH2:15][CH2:14][N:13]2[S:18]([C:21]2[CH:26]=[CH:25][C:24]([CH:27]3[CH2:29][CH2:28]3)=[CH:23][CH:22]=2)(=[O:20])=[O:19])=[O:11])=[CH:6][CH:5]=1.Cl[C:35]1[S:36][C:37]2[C:42]([Cl:43])=[N:41][C:40]([CH:44]3[CH2:46][CH2:45]3)=[N:39][C:38]=2[N:47]=1.C(N(CC)C(C)C)(C)C>C(Cl)(Cl)Cl.C(OCC)(=O)C>[F:33][C:2]([F:1])([F:32])[O:3][C:4]1[CH:31]=[CH:30][C:7]([CH2:8][NH:9][C:10]([C@H:12]2[CH2:17][N:16]([C:35]3[S:36][C:37]4[C:42]([Cl:43])=[N:41][C:40]([CH:44]5[CH2:45][CH2:46]5)=[N:39][C:38]=4[N:47]=3)[CH2:15][CH2:14][N:13]2[S:18]([C:21]2[CH:26]=[CH:25][C:24]([CH:27]3[CH2:28][CH2:29]3)=[CH:23][CH:22]=2)(=[O:19])=[O:20])=[O:11])=[CH:6][CH:5]=1