Acetone → 3-(4-Isopropyl-piperazin-1-yl)-phenol

HRID 910274

反応式

HRID 910274 の反応式
[CH3:1][C:2]([CH3:4])=O.[BH-](OC(C)=O)(OC(C)=O)OC(C)=O.[Na+].[N:19]1([C:25]2[CH:26]=[C:27]([OH:31])[CH:28]=[CH:29][CH:30]=2)[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1.C(=O)(O)[O-].[Na+]>C1COCC1>[CH:2]([N:22]1[CH2:21][CH2:20][N:19]([C:25]2[CH:26]=[C:27]([OH:31])[CH:28]=[CH:29][CH:30]=2)[CH2:24][CH2:23]1)([CH3:4])[CH3:1]

参加物

6

反応物 4

HCID 180AcetoneHCID 516892Sodium BicarbonateHCID 27365971-(3-Hydroxyphenyl)piperazineHCID 5049666Sodium triacetoxyborohydride

生成物 1

HCID 584994803-(4-Isopropyl-piperazin-1-yl)-phenol収率 59.9%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Acetone (1.95 g) and NaBH(OAc)3 (7.12 g) were added to a solution of 3-piperazin-1-yl-phenol (2.00 g) in THF (40 ml), and the mixture was stirred at room temperature for 18 hours. Saturated aqueous sodium bicarbonate was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was dried (MgSO4) and filtered to give the titled compound (1.48 g, colorless powder).

後処理

  1. extractionthe mixture was extracted with ethyl acetate
  2. dry with materialThe organic layer was dried (MgSO4)
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-f0cc949488174e2aa69b178879108f42
出典データセット
uspto-grants-2011_09
特許番号
US08022091B2

関連ノート

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