Methyl chloroformate → Methyl (2-(hydroxymethyl)phenyl)carbamate

反応式

N[CH:2]([OH:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH3:10][O:11][C:12](Cl)=[O:13].CC[N:17](C(C)C)C(C)C>>[CH3:10][O:11][C:12](=[O:13])[NH:17][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[CH2:2][OH:9]

参加物

反応物 3

HCID 6586Methyl chloroformate

HCID 81531Diisopropylethylamine

HCID 5250324HCID 5250324、化合物

生成物 1

HCID 54236756Methyl (2-(hydroxymethyl)phenyl)carbamate

実験手順

Reaction of aminobenzylalcohol (3 g) with methylchloroformate (1.9 ml) in the presence of DIPEA (12.8 ml) was performed according to the method described in example 22. The residue was chromatographed on silica gel in dichloromethane/ethyl acetate=25/1 as eluent. Yield: 4.19 g.