2,6-Dimethylphenol → 2-Chloro-4-(2,6-dimethylphenoxy)pyridine

HRID 910992

反応式

HRID 910992 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[OH:9].[H-].[Na+].[Cl:12][C:13]1[CH:18]=[C:17]([N+]([O-])=O)[CH:16]=[CH:15][N:14]=1>>[Cl:12][C:13]1[CH:18]=[C:17]([O:9][C:3]2[C:4]([CH3:8])=[CH:5][CH:6]=[CH:7][C:2]=2[CH3:1])[CH:16]=[CH:15][N:14]=1

参加物

4

反応物 3

HCID 113352,6-DimethylphenolHCID 24758Sodium hydrideHCID 7351522-Chloro-4-nitropyridine

生成物 1

HCID 866347362-Chloro-4-(2,6-dimethylphenoxy)pyridine収率 96.3%

実験手順

Using the method of Example 3, Step A, 2,6-dimethylphenol (0.771 g, 6.31 mmol), 60% sodium hydride in mineral oil (252 mg, 6.31 mmol), and 2-chloro-4-nitropyridine (1.00 g, 6.31 mmol) were reacted to provide 2-chloro-4-(2,6-dimethylphenoxy)pyridine (1.42 g, 96% yield) as a white solid. 1H NMR (CDCl3) δ 8.20 (d, 1H), 7.12 (s, 4H), 6.65-6.68 (m, 2H), 2.11 (s, 6H).

後処理

  1. customwere reacted

出典と根拠

ORDレコード
ord-4063f08ca8f346c7ad8604fa9a1f063c
出典データセット
uspto-grants-2011_09
特許番号
US08022222B2

関連ノート

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