Sodium Hydroxide → 1-(4-(4-Methoxybenzylthio)-5-bromopyridin-2-yl)thiourea
反応式
[CH3:1][O:2][C:3]1[CH:29]=[CH:28][C:6]([CH2:7][S:8][C:9]2[C:14]([Br:15])=[CH:13][N:12]=[C:11]([NH:16][C:17]([NH:19]C(=O)C3C=CC=CC=3)=[S:18])[CH:10]=2)=[CH:5][CH:4]=1.[OH-].[Na+]>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][S:8][C:9]2[C:14]([Br:15])=[CH:13][N:12]=[C:11]([NH:16][C:17]([NH2:19])=[S:18])[CH:10]=2)=[CH:28][CH:29]=1参加物
4
反応条件
- 温度
- 65 °C
実験手順
1-(4-(4-methoxybenzylthio)-5-bromopyridin-2-yl)-3-benzoylthiourea (8.50 g, 17.4 mmol) was suspended in THF (150 mL). NaOH (116 ml, 348 mmol) was added, and the reaction was stirred at 65° C. overnight. The solution was cooled and filtered, and the solids were washed with cold water. The solids were then triturated in EtOH and filtered to provide the desired product (5.3 g, 79% yield) as a tan solid.