Sodium Hydroxide → 1-(4-(Benzyloxy)-5-bromopyridin-2-yl)thiourea
反応式
C([NH:9][C:10]([NH:12][C:13]1[CH:18]=[C:17]([O:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[C:16]([Br:27])=[CH:15][N:14]=1)=[S:11])(=O)C1C=CC=CC=1.[OH-].[Na+]>C1COCC1>[CH2:20]([O:19][C:17]1[C:16]([Br:27])=[CH:15][N:14]=[C:13]([NH:12][C:10]([NH2:9])=[S:11])[CH:18]=1)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1参加物
4
反応条件
- 温度
- 60 °C
実験手順
A flask was charged with 1-benzoyl-3-(4-(benzyloxy)-5-bromopyridin-2-yl)thiourea (9.8 g, 22.2 mmol) and THF (200 mL). 6N NaOH (100 mL) and NaOH (5 g) were added. The reaction was stirred at 60° C. for 3 hours, then concentrated and filtered to give the desired product (2.54 g, 33.9% yield) as off white solid.
後処理
- concentrationconcentrated
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-0b6e172ff48a46338ae2af8944f9d1fb
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08022222B2
反応ノート
読み込み中…