反応式
[CH3:1][C:2]1[N:7]=[C:6]([CH:8]=[O:9])[CH:5]=[CH:4][CH:3]=1.[CH3:10][Mg]Br.CCOCC>C1COCC1>[OH:9][CH:8]([C:6]1[CH:5]=[CH:4][CH:3]=[C:2]([CH3:1])[N:7]=1)[CH3:10]参加物
5
実験手順
To 6-methylpyridine-2-carboxaldehyde (2.0 g, 16.5 mmol) in dry THF (55 mL) at 0° C. under nitrogen, add a solution of 3M methyl magnesium bromide in ether (6.0 mL, 18.0 mmol) dropwise with stirring. After 1 h at 0° C., quench with saturated aqueous NH4Cl, extract three times with EtOAc, dry over anhydrous Na2SO4 and concentrate in vacuo to give the desired intermediate (crude, 2.3 g).
後処理
- customquench with saturated aqueous NH4Cl
- extractionextract three times with EtOAc
- dry with materialdry over anhydrous Na2SO4
- concentrationconcentrate in vacuo
出典と根拠
- ORDレコード
- ord-e4e089cff6174624942de9363c4cc38b
- 出典データセット
- uspto-grants-2011_09
- 特許番号
- US08022062B2
関連ノート
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