Acetonitrile → HCID 59244915、化合物

HRID 912246

反応式

HRID 912246 の反応式
Br[CH2:2][CH2:3][C:4]1[CH:5]=[C:6]([Br:10])[CH:7]=[CH:8][CH:9]=1.[C:11]([O:15][C:16]([N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1)=[O:17])([CH3:14])([CH3:13])[CH3:12].C(=O)([O-])[O-].[K+].[K+].C(#N)C>C(OCC)(=O)C>[C:11]([O:15][C:16]([N:18]1[CH2:23][CH2:22][N:21]([CH2:2][CH2:3][C:4]2[CH:5]=[C:6]([Br:10])[CH:7]=[CH:8][CH:9]=2)[CH2:20][CH2:19]1)=[O:17])([CH3:14])([CH3:12])[CH3:13]

参加物

6

反応物 4

HCID 6342AcetonitrileHCID 11430Potassium CarbonateHCID 143452tert-Butyl piperazine-1-carboxylateHCID 143612163-Bromophenethyl bromide

生成物 1

HCID 59244915HCID 59244915、化合物収率 92.2%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To 3-(2-bromo-ethyl)-1-bromo-benzene (0.15 ml, 1 mmol), 1-tert-butoxycarbonyl-piperazine (186 mg) and potassium carbonate (280 mg), acetonitrile (4 ml) was added, followed by stirring for 4 days. To the reaction mixture, ethyl acetate was added, which was washed with ammonium chloride solution, followed by drying over sodium sulfate. After filtering off the drying agent, the filtrate was concentrated under reduced pressure, to obtain 3-(2-(4-tert-butoxycarbonyl-piperazin-1-yl)-ethyl)-1-bromo-benzene as a colorless oil (340 mg, 92%).

後処理

  1. washwhich was washed with ammonium chloride solution
  2. dry with materialby drying over sodium sulfate
  3. filtrationAfter filtering off the drying agent
  4. concentrationthe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-593da5778212483a84c2edee09c15c65
出典データセット
uspto-grants-2011_09
特許番号
US08022205B2

関連ノート

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