O-Methylhydroxylamine hydrochloride → 5-tert-butyl-1-indanone O-methyloxime

HRID 912629

反応式

HRID 912629 の反応式
[C:1]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[C:10](=O)[CH2:9][CH2:8]2)([CH3:4])([CH3:3])[CH3:2].Cl.[CH3:16][O:17][NH2:18]>N1C=CC=CC=1>[CH3:16][O:17][N:18]=[C:10]1[C:11]2[C:7](=[CH:6][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:13][CH:12]=2)[CH2:8][CH2:9]1

参加物

4

反応物 2

HCID 521874O-Methylhydroxylamine hydrochlorideHCID 110305765-Tert-butyl-2,3-dihydroinden-1-one

生成物 1

HCID 730474605-tert-butyl-1-indanone O-methyloxime

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

5-tert-Butyl-1-indanone (13.41 g, 71.23 mmol) and methoxyamine hydrochloride (6.68 g, 80 mmol) were disolved in pyridine (75 ml) and stirred at ambient temperature for 16 hours. The mixture was evaporated under reduced pressure and the residue was partitioned between water and diethyl ether (X2). The combined organic layers were washed with 1N aqueous hydrochloric acid, dried with magnesium sulfate, and the filtrate was evaporated under reduced pressure to provide the title compound which was used without further purification in the next step.

後処理

  1. customThe mixture was evaporated under reduced pressure
  2. customthe residue was partitioned between water and diethyl ether (X2)
  3. washThe combined organic layers were washed with 1N aqueous hydrochloric acid
  4. dry with materialdried with magnesium sulfate
  5. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-21d60427599a4c2cb94d0b704c1d126c
出典データセット
uspto-grants-2011_09
特許番号
US08026256B2

関連ノート

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