Hydrochloric Acid → Cephalexin

HRID 914651

反応式

HRID 914651 の反応式
[CH3:1][C:2]1[CH2:11][S:10][C@@H:5]2[C@H:6]([NH2:9])[C:7](=[O:8])[N:4]2[C:3]=1[C:12]([OH:14])=[O:13].[CH:15]1[CH:20]=[CH:19][C:18]([CH:21]([NH2:25])[C:22](N)=[O:23])=[CH:17][CH:16]=1.CC1(C)S[C@@H]2[C@H](NC(CC3C=CC=CC=3)=O)C(=O)N2[C@H]1C([O-])=O.[K+].Cl>>[CH3:1][C:2]1[CH2:11][S:10][C@@H:5]2[C@H:6]([NH:9][C:22]([C@H:21]([NH2:25])[C:18]3[CH:17]=[CH:16][CH:15]=[CH:20][CH:19]=3)=[O:23])[C:7](=[O:8])[N:4]2[C:3]=1[C:12]([OH:14])=[O:13]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 127912-Amino-2-phenylacetamideHCID 334987-Aminodeacetoxycephalosporanic acidHCID 23664709Penicillin G Potassium

生成物 1

HCID 27447Cephalexin

実験手順

The reaction is carried out at 25° C. and pH 7.5 in a fixed bed reactor. 10 ml of an aqueous solution of a mixture 0.2 M 7-ADCA and 0.2 M D-phenylglycinamide are passed through a column with 0.5 ml of the immobilized penicillin amidase. During the reaction, the pH is kept constant by adding HCl in an attached stirred reservoir container. Samples are taken and analyzed by HPLC as shown in example 5 at particular time intervals.

後処理

  1. customis carried out at 25° C.
  2. customDuring the reaction

出典と根拠

ORDレコード
ord-76ae13ba93db4ce78e8e70f1e9a58fcd
出典データセット
uspto-grants-2007_09
特許番号
US07264943B2

関連ノート

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