2,3-Dichloro-5,6-dicyano-1,4-benzoquinone → N-Ethyl-N'-(8-methyl-5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)urea

HRID 9156

反応式

HRID 9156 の反応式
[S:1]1[C:12]2[C:11]3[NH:10][CH:9]=[CH:8][C:7]=3[CH2:6][CH2:5][C:4]=2[N:3]=[C:2]1[NH:13][C:14]([NH:16][CH2:17][CH3:18])=[O:15].[C:19](C1C(=O)C(Cl)=C(Cl)C(=O)C=1C#N)#N>C1(C)C=CC=CC=1>[CH2:17]([NH:16][C:14]([NH:13][C:2]1[S:1][C:12]2[C:11]3[N:10]([CH3:19])[CH:9]=[CH:8][C:7]=3[CH2:6][CH2:5][C:4]=2[N:3]=1)=[O:15])[CH3:18]

参加物

4

反応物 2

HCID 67752,3-Dichloro-5,6-dicyano-1,4-benzoquinoneHCID 21985605N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N'-ethylurea

生成物 1

HCID 21985619N-Ethyl-N'-(8-methyl-5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)urea

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
45 °C

実験手順

To a suspension of N-(5,8-dihydro-4H-[1,3]thiazolo[4,5-g]indol-2-yl)-N′-ethylurea in toluene is added DDQ (1.1 eq.). The reaction mixture is stirred at about 45° C. for about 4 hrs. The reaction mixture is pumped down and the crude material is purified by preparative HPLC.

後処理

  1. customthe crude material is purified by preparative HPLC

出典と根拠

ORDレコード
ord-2df8a4191bd44591b7d0af914e3af49b
出典データセット
uspto-grants-2006_08
特許番号
US07091227B2

関連ノート

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